niacin and statins interaction

Authors and Disclosures. The Coronary Drug Project was a pre-statin era secondary prevention trial that randomized 1,119 subjects to clofibrate or niacin. Do not drink more than 1 quart of grapefruit juice daily. Authors and Disclosures Journalist Patrice Wendling. Yes. The study is created by eHealthMe based on reports of 466 people who take Crestor and Niacin from the FDA, and is updated regularly. ... Information on the interaction between statins and fish oils and omega-3 fatty acids. You may have read that niacin or niacinamide has a positive effect on cholesterol profile, and that some cholesterol drugs are “knockoffs” of vitamin B3. Drug interactions are reported among people who take Crestor and Niacin. Cite this: FDA Pulls Approval of Niacin, Fibrate in Combo with Statins - Medscape - Apr 15, 2016. Niacin-simvastatin Interactions Grapefruit and grapefruit juice may interact with simvastatin and lead to potentially dangerous effects. Taking niacin with alcohol might increase the risk of liver damage and worsen niacin side effects, such as flushing and itching. Prescription niacin might benefit people with high cholesterol who aren't able to take statins or haven't been able to control their cholesterol levels through use of a statin, ... Possible interactions include: Alcohol. Nevertheless, some physicians believe taking niacin in addition to statin medication may be helpful for certain people; however do not try this combination without consulting your physician. References. Common interactions include oedema peripheral among females and fatigue among males. Why are statins pushed when instead, it seems that the safer route is to just take high doses of niacin (vitamin B3) to lower cholesterol? The interaction of statins with fibrates deserves particular attention because myopathy can occur with either drug alone, and the effects may be additive. Our commentator has given this study a ranking of "Changes Clinical Practice," with the conclusion that extended-release niacin-laropiprant should no longer be given to statin-treated patients. This is mainly due to adverse drug interactions that can occur and concern that niacin often carries more risks than benefits for people on statin therapy. But you should know that niacin is no longer recommended as a first-line therapy when using statins.

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